Research Catalog

Title

Applied biopharmaceutics & pharmacokinetics / Leon Shargel, Susanna Wu-Pong, Andrew B.C. Yu.

Author

Shargel, Leon, 1941-

Publication

New York : Appleton & Lange Reviews/McGraw-Hill, Medical Pub. Division, [2005], ©2005.

Items in the Library & Off-site

Details

Additional Authors

• Wu-Pong, Susanna.
• Yu, Andrew B. C., 1945-

Description

xx, 892 pages : illustrations; 24 cm

Summary

"Applied Biopharmaceutics and Pharmacokinetics provides the reader with a basic understanding of the principles of biopharmaceutics and pharmacokinetics as applied to drug product development and drug therapy. The revised and updated fifth edition of this popular text remains unique in teaching the student the basic concepts that may be applied to understanding the complex issues associated with the processes of drug delivery and the essentials of safe and effective drug therapy."--BOOK JACKET.

Alternative Title

Applied biopharmaceutics and pharmacokinetics

Subjects

• Biopharmaceutics
• Models, Chemical
• Pharmacokinetics

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Introduction to biopharmaceutics and pharmacokinetics -- 2. Mathematic fundamentals in pharmacokinetics -- 3. One-compartment open model : intravenous bolus administration -- 4. Multicompartmental models : intravenous bolus administration -- 5. Intravenous infusion -- 6. Drug elimination and clearance -- 7. Pharmacokinetics of oral absorption -- 8. Multiple dosage regimens -- 9. Nonlinear pharmacokinetics -- 10. Physiologic drug distribution and protein binding -- 11. Hepatic elimination of drugs -- 12. Pharmacogenetics -- 13. Physiologic factors related to drug absorption -- 14. Biopharmaceutic considerations in drug product design -- 15. Bioavailability and bioequivalence -- 16. Impact of drug product quality and biopharmaceutics on clinical efficacy -- 17. Modified-release drug products -- 18. Targeted drug delivery systems and biotechnological products -- 19. Relationship between pharmacokinetics and pharmacodynamics -- 20. Application of pharmacokinetics in clinical situations -- 21. Dose adjustment in renal and hepatic disease -- 22. Physiological pharmacokinetic models, mean resident time, and statistical moment theory -- App. A. Statistics -- App. B. Applications of computers in pharmacokinetics -- App. C. Ethical considerations -- App. D. Solutions to frequently asked questions (FAQ) and learning questions -- App. E. Popular drugs and pharmacokinetic parameters.

ISBN

• 0071375503
• 0071375511

LCCN

2004044993

OCLC

• ocm54536683
• SCSB-5081416

Owning Institutions

Columbia University Libraries