Research Catalog

Title

Introduction to macromolecular crystallography / Alexander McPherson.

Author

McPherson, Alexander, 1944-

Publication

Hoboken, N.J. : Wiley-Liss, c2003.

Items in the Library & Off-site

Details

Description

x, 237 p. : ill.; 26 cm.

Subjects

• X-ray crystallography
• Macromolecules > Structure

Bibliography (note)

• Includes bibliographical references (p. 227-229) and index.

Contents

An overview of macromolecular crystallography -- What do we mean by the structure of something? -- An analogy -- A lens -- How x-ray diffraction works -- The phase problem -- The electron density -- The nature of crystals : symmetry and the unit cell -- The asymmetric unit -- The space group -- The unit cell -- The lattice translations -- Symmetry and equivalent positions -- Why so few kinds of unit cells? -- Primitive and centered lattices -- Planes, Miller indices, and convolutions -- The reciprocal lattice -- Crystals as waves of electrons in three-dimensional space -- Waves and their properties -- Waves as vectors and complex numbers -- Addition of waves -- Vector arithmetic -- Some useful wave relationships -- The Fourier synthesis, planes, and the electron density -- Diffraction from points, planes, molecules and crystals -- The diffraction pattern from an arbitrary array of points in space -- Diffraction from equally spaced points along a line -- Diffraction from a plane, families of planes, and lattices of points -- Continuous and discontinuous transforms -- The structure factor equation for a crystal -- Temperature factors -- Center of symmetry -- Friedel's law and anomalous scattering -- Anomalous dispersion effects -- The electron density equation -- Examination of diffraction patterns -- Ewald's sphere and Bragg's law -- Crystal symmetry and the symmetry of the diffraction pattern -- Symmetry and systematic absences -- Analysis of diffraction patterns -- More thoughts on space groups -- Solving the phase problem -- Patterson methods -- The heavy atom method -- The R factor and crystallographic refinement -- Isomorphous replacement -- Formulation of isomorphous replacement in protein crystallography -- Isomorphous replacement in practice -- Molecular replacement -- Phase extension using noncrystallographic symmetry -- Anomalous scattering approaches -- Direct methods -- Interpreting Patterson maps -- Interpreting the Patterson map -- Harker vectors and peaks -- Using the Patterson map for isomorphous replacement -- Electron density maps and difference Fourier maps -- Interpretation -- Criteria for judging a structure determination -- Biochemical experiment using x-ray crystallography -- The difference Fourier method.

Call Number

JSF 02-1011

ISBN

0471251224 (acid-free paper)

LCCN

2002008985

OCLC

vendor

Author

McPherson, Alexander, 1944-

Title

Introduction to macromolecular crystallography / Alexander McPherson.

Imprint

Hoboken, N.J. : Wiley-Liss, c2003.

Bibliography

Includes bibliographical references (p. 227-229) and index.

Research Call Number

JSF 02-1011