Research Catalog

Title

Signal transduction / Bastien D. Gomperts, Peter E.R. Tatham, IJsbrand M. Kramer.

Author

Gomperts, B. D.

Publication

San Diego, Calif. : Academic Press, ©2002.

Items in the Library & Off-site

Details

Additional Authors

• Tatham, Peter E. R. (Life scientist)
• Kramer, Ijsbrand M.

Description

xiv, 424 pages : illustrations (some color); 26 cm

Summary

Signal Transduction is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particularly cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources, key observations and experiments that set the scene for recent and current work.

Subjects

• Cellular signal transduction
• Signalen
• Signaltransduktion
• 42.15 cytology, cell biology and cell physiology
• Signal Transduction

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Prologue: Signal transduction, origins and personalities -- 2. First messengers -- 3. Receptors -- 4. GTP-binding proteins and signal transduction -- 5. Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C -- 6. The regulation of visual transduction -- 7. Calcium and signal transduction -- 8. Calcium signalling -- 9. Phosphorylation and dephosphorylation: Protein kinases A and C -- 10. Growth factors: Setting the framework -- 11. Signalling pathways operated by receptor protein tyrosine kinases -- 12. Signalling pathways operated by non-receptor protein tyrosine kinases -- 13. Phosphoinositide 3-kinases, protein kinase B and signalling through the insulin receptor.

ISBN

• 0122896319
• 9780122896316
• 0122896327
• 9780122896323

LCCN

2001096954

OCLC

• ocm48752824
• 48752824
• SCSB-1258015

Owning Institutions

Princeton University Library