Research Catalog

Title

Essential concepts in toxicogenomics / edited by Donna L. Mendrick, William B. Mattes.

Publication

Totowa, N.J. : Humana ; [London] : [Springer, distributor], [2008], ©2008.

Items in the Library & Off-site

Details

Additional Authors

• Mendrick, Donna L.
• Mattes, William B.

Description

xi, 277 pages, 8 pages of plates : illustrations (some color); 25 cm.

Series Statement

Methods in molecular biology ; 460

Uniform Title

Methods in molecular biology ; v. 460.

Subjects

• Genomics
• Toxicogenetics
• Genetic toxicology

Bibliography (note)

• Includes bibliographical references and index.

Contents

1. Toxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity / Donna L. Mendrick -- 2. Use of Traditional End Points and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology / Wayne R. Buck, Jeffrey F. Waring and Eric A. Blomme -- 3. Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications / Karol L. Thompson and Joseph Hackett -- 4. Role of Statistics in Toxicogenomics / Michael Elashoff -- 5. Predictive Toxicogenomics in Preclinical Discovery / Scott A. Barros and Rory B. Martin -- 6. In Vivo Predictive Toxicogenomics / Mark W. Porter -- 7. Bioinformatics: Databasing and Gene Annotation / Lyle D. Burgoon and Timothy R. Zacharewski -- 8. Microarray Probe Mapping and Annotation in Cross-Species Comparative Toxicogenomics / John N. Calley, William B. Mattes and Timothy P. Ryan -- 9. Toxicogenomics in Biomarker Discovery / Marc F. DeCristofaro and Kellye K. Daniels -- 10. From Pharmacogenomics to Translational Biomarkers / Donna L. Mendrick -- 11. Public Consortium Efforts in Toxicogenomics / William B. Mattes -- 12. Applications of Toxicogenomics to Nonclinical Drug Development: Regulatory Science Considerations / Frank D. Sistare and Joseph J. DeGeorge.

ISBN

• 9781588296382 (hbk.)
• 1588296385 (hbk.)
• 9781603270489 (e-book)
• 1603270485 (e-book)

LCCN

2008921701

OCLC

• ocn182528158
• 182528158
• SCSB-5412100

Owning Institutions

Columbia University Libraries